LONG-TERM CALORIC RESTRICTION PREVENTS AGE-RELATED LEARNING IMPAIRMENT VIA SUPPRESSION OF APOPTOSIS
نویسندگان
چکیده
منابع مشابه
Activation-Induced Apoptosis in T cells: Effect of Age and Caloric Restriction
We have previously shown that the proliferative response of T cells to antigenic or mitogenic stimulus decreased with age and that caloric resection (CR) attenuated the age-related decline in proliferation and IL-2 expression. Because activation-induced apoptosis is known to regulate cell proliferation and eliminate the high number of activated cells during an immune response, it was of interes...
متن کاملLong-term caloric restriction abrogates the age-related decline in skeletal muscle aerobic function.
The purpose of this study was to determine the effect of long-term caloric restriction (CR) on the age-associated decline of skeletal muscle aerobic function. Skeletal muscle maximal aerobic performance (VO2max) was assessed in ad libitum (AL) and CR rats aged 8-10 months and 35 months using a pump-perfused hindlimb model to match oxygen delivery to muscle mass between groups. Whereas there was...
متن کاملThe age-related paraoxonase 1 response is altered by long-term caloric restriction in male and female rats.
Caloric restriction (CR) has been shown to attenuate age-related oxidative damage and to improve major atherosclerotic risk factors. Paraoxonase 1 (PON1), an enzyme specifically associated with HDL containing apolipoproteins A-I and J, has been reported to prevent the proatherosclerotic effects of oxidized LDL. The aim of this study was to evaluate whether modulation of PON1 activity is part of...
متن کاملactivation-induced apoptosis in t cells: effect of age and caloric restriction
we have previously shown that the proliferative response of t cells to antigenic or mitogenic stimulus decreased with age and that caloric resection (cr) attenuated the age-related decline in proliferation and il-2 expression. because activation-induced apoptosis is known to regulate cell proliferation and eliminate the high number of activated cells during an immune response, it was of interes...
متن کاملCardioprotective Signature of Short-Term Caloric Restriction
OBJECTIVE To understand the molecular pathways underlying the cardiac preconditioning effect of short-term caloric restriction (CR). BACKGROUND Lifelong CR has been suggested to reduce the incidence of cardiovascular disease through a variety of mechanisms. However, prolonged adherence to a CR life-style is difficult. Here we reveal the pathways that are modulated by short-term CR, which are ...
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ژورنال
عنوان ژورنال: Innovation in Aging
سال: 2017
ISSN: 2399-5300
DOI: 10.1093/geroni/igx004.614